Abstract: Cost of soybeans meal contribute high percentage of total cost of feed in rabbit’s production in developing countries apart from the maize, therefore experiment was carried out to investigate the effect of replacing soybeans meal with Ipomoea asarifolia leaf meal (IALM) as a plant protein for rabbit production and gut responses, apparent nutrient digestibility were therefore investigated. Twenty-four weaned, 6-8 weeks old rabbits, were randomly allotted to four dietary treatments in which IALM was used to replaced soybean meal (SBM) at 0% (T1, control), 10% (T2), 20% (T3), and 30% (T4), with six (6) rabbits per treatment in a completely randomized design experiment. Each rabbit served as a replicate. Feed and water were offer ad libitum while other standard management practices were observed. Relative organs and gut weight and length were determined using sensitive digital scale and tape rule respectively, while apparent nutrient digestibility, gut histomorphometry were evaluated following standard procedures. Data were analysed using ANOVA at α0.05. Control rabbits had the highest value for villus height (77.68µm), villus width (13.99 µm) and crypt depth (38.03µm) while the largest relative gut weight was caecum with the value ranges from 5.33% (treatment 3, 20%IALM) to 7.51% (treatment 4, 30%IALM). The longest relative gut length (19.16) was obtained in treatment T4 (30%IALM). Other relative organ weights were not affected by dietary treatment except abdominal fat with highest values under T3 and T4 and nutrients were highly digested under control diet than other treatments. It was concluded that soybeans can be replaced with IALM up to 30% without having negative effect on gut response, organs weight and nutrients digestibility.