Abstract: Foreign direct investment (FDI) inflows are often seen as one factor contributing to economic growth. Therefore, considerable attention is paid in examining its determinants. Human capital, labor force, macroeconomic stability, infrastructure are often perceived as potential determinants of FDI. However, there is mixed evidence of the relationship between FDI and economic growth in the empirical literature. This paper used time series econometric tests including Augmented Dickey – Fuller (ADF) unit root test, Kwiatkowski-Philips-Schmidt-Shin (KPSS) stationary test, ARDL co-integration test and Granger causality test to analyze the relationship between FDI and Economic growth in Niger. The test results showed a long run-relationship between the variables. Two bilateral relationships and twelve (12) unidirectional causal relationships are found between the variables. The results also revealed that FDI, human capital and macroeconomic stability have a positive relationship with economic growth while labor force, physical capital and trade have a negative relationship with economic growth.