Abstract: Introduction: The cerebellar mutism syndrome is a neurological condition which has been seen in children and only rarely described in adults after surgery of the posterior fossa. It usually appears as a consequence of posterior fossa surgery in children with cerebellar or fourth ventricle tumors. Objectives: It is a case report of an adolescent girl from Bangladesh presenting with postoperative cerebellar mutism. Case: The 15-year-old young, student initially presented with headache of raised intracranial pressure due to obstruction. She developed mutism on the second postoperative day following Surgery for astrocytoma of fourth ventricle. By the second and third post-operative day, her responses to query had almost stopped, but to persistent queries she gave a single word response and it was restricted to either ‘yes’ or ‘no’. She remained silent and kept her eyes closed most of the time and cried for any attempts to wake her. She had mood instability with sudden unprovoked laughter followed by cry. She ate what she was fed and did not have any difficulty swallowing. Conclusion: To the authors’ best knowledge, this is first case report of the cerebellar mutism in Bangladesh which would help the clinicians to deal with syndrome.