Background: Maxillary midline diastema is one of the most frequently encountered esthetic problems in mixed and permanent dentition. Several causes have been attributed to the midline diastema, including developmental, pathologic or iatrogenic. It can also be seen as a transient malocclusion in which case any intervention is contraindicated. A wide range of possible treatments like restorative procedures, composite build up, surgeries (frenectomies) can be done, based on etiology. Thus, correct diagnosis of etiology and specific early intervention plays a major role in deciding the treatment plan. Case report: This case report evaluates the management of Class I malocclusion with spaced anterior dentition in a 32 year old male patient with maxillary midline diastema and a generalized spaced upper and lower dentition. The upper arch midline diastema can be attributed to presence of a thick band of fibrous tissue between the upper central incisors. The case was treated with routine fixed orthodontic therapy and frenectomy was performed at the end of the treatment just before closure of midline diastema space to prevent scar tissue formation. Conclusion: Maxillary and mandibular arch spaces were closed down . The dental changes and treatment results were demonstrated. This case report illustrates the interdisciplinary collaboration of an Orthodontist and Periodontist for treatment of such a case. With proper case selection, planning and good patient cooperation, we could obtain significant results.