A problem often confronting the orthodontist is that of missing upper incisors. In evaluation of the individual case, the decision as to space closure or space regaining and eventual prosthetic reconstruction can be perplexing. Various diagnostic criteria, such as skeletal relation, arch-length analysis, inclination of teeth, and dental esthetics, must be evaluated. On the basis of this diagnostic information, a treatment alternative is chosen to correct the malocclusion. The solution may be found in maintaining space, necessitating post-orthodontic prosthetic replacement, or closing space and thus avoiding the need for artificial teeth. This case report evaluates the management of a 28 year old female patient having a mutilated malocclusion with missing maxillary central incisors. It was managed by routine orthodontic treatment which involved creating space for the missing central incisors followed by aesthetic replacement with prosthesis. After the treatment, a marked improvement in patient's smile, facial profile and occlusion was achieved and there was a remarkable increase in the patient's confidence and quality of life. Excellent occlusion and correction of the mutilated malocclusion were achieved without tipping, rotation of the posterior teeth, or other problems. The profile changes and treatment results were demonstrated with proper case selection and good patient cooperation with fixed appliance therapy.