This study investigated socio-cultural variables as correlate of youths’ vulnerability to suicide in Ekiti state, Nigeria. Specifically, the study considered the relationships of gender, religious affiliation and educational attainment with youth vulnerability to suicide. Descriptive research design of the exploratory type was adopted for the study. The population comprised of both male and female youth in Ekiti state while the sample consisted of 300 youths selected through stratified random sampling technique. The instrument for the study was a questionnaire designed by the researchers. The validity of the instrument was done through face and content validity procedures while Cronbach alpha was used for the reliability. The reliability coefficient of 0.79 was obtained. Three research hypotheses were generated and tested at 0.05 level of significance. The data collected were analysed using Frequency count, Mean, Standard Deviation and Pearson Product Moment Correlation statistical tools. The study found that there is relationship between gender, religious affiliation, educational attainment and youth vulnerability to suicide in Ekiti state. It was therefore recommended that parents should make provisions for their children without gender discrepancy. Parents should also give sound education to their children, religious leaders should preach against suicide and government should provide functional education and jobs for youths.