The study investigated teachers’ perception of the influence of large classes on the teaching and learning of English language in Ado Ekiti metropolis. The descriptive research design of the survey type was adopted as the Research Design for the study. The Population consisted of all English language teachers teaching English language in all the public secondary schools in the metropolis. The sample comprised eight public secondary schools randomly selected from the population and all the thirty teachers teaching English language in the selected schools were the respondents. The instrument for data collection was a questionnaire designed by the researcher titled ‘Teachers’ Perception of the Influence of Large Classes on the Teaching and Learning of English Language’. The instrument was subjected to validity and reliability tests and the reliability coefficient of 0.72 was obtained. The researcher personally visited the selected schools to administer the instrument. Data collected were analysed using both descriptive and inferential statistics. The result showed that teachers perceived the influence of large classes on the teaching and learning of English language in terms of difficulty in teaching and learning; which include: difficulty in knowing all the students in the class, frustration on the part of the teacher, inadequate teaching resources, poor classroom interaction, poor classroom arrangement and above all, poor academic performance on the part of the students. Also, teachers perceived that large classes can be managed using appropriate methods. Based on the findings, it is recommended that government at all levels should make provision to improve on existing school facilities in order to make more classrooms and other facilities available to accommodate smaller classes and where large classes exist presently, the English language teachers should be trained on how to effectively manage large classes for more effective teaching and learning.