Ho Chi Minh City is not only known as the economic locomotive of Vietnam but also a city with diverse cultures. Public art and Ho Chi Minh Cultural Space play an important role in the strategy of sustainable development and improving the human development index. The research is carried out for the purpose of providing an overview of the formation and development of public art in Ho Chi Minh City. Ho Chi Minh City and find out the influencing factors, the relationship between public art and cultural space; thereby building some solutions to connect the public art and cultural space of Ho Chi Minh to keep the soul and promote cultural values in the economic locomotive city in Vietnam. With the methods of document research, analysis, synthesis, and field survey, the study assessed the current state of public art in Ho Chi Minh City and point out its role with Ho Chi Minh Cultural Space in the current context.