The study was conducted using twenty four West African Dwarf (WAD) goats with average weight of 6.74 ± 0.33kg to investigate the effect of raw composite cashew nut shell (CNS) meal on blood profile. The goats were assigned to four dietary treatments with five replicate per treatment in a completely randomized design. The raw cashew nut shell was sun-dried and crushed to less than 1 mm particle size and included at 0% (diet A), 5% (diet B), 10% (diet C) and 15% (diet D) with other conventional feed ingredients to formulate a complete diet. The animals were stabilized for two weeks while the experimental period lasted 63days. After the feeding trial, blood sample of 5ml was collected from each goat via the jugular vein puncture into a sterilized Ethylene Diaminetetra Acetate Acid (EDTA) bottles to prevent coagulation for haematological assay while another 5ml sample was collected in bottles without EDTA for serum biochemical indices. The results of the chemical composition showed that the dry matter ranged from 74.49 – 82.87% while the crude protein ranged from 7.16 – 7.89%. The raw cashew nut shell significantly (P < 0.05) influenced the lymphocytes which ranged from 45.67% (diet D) – 61.67% (diet A) but serum biochemical indices were not significantly influenced except in the high density lipoprotein (HDL) and no significant (P > 0.05) difference was also observed in the serum electrolytes. Based on the findings of this study, raw composite cashew nut shell had no detrimental effect on the blood profile of WAD buck, thus, raw CNS could serve as a substantial alternative feed ingredient in ruminant production.