Although gender based periodontal therapy is questionable the advent of chronic autoimmune induced hypothyroidism [Hashimotos thyroiditis [HT] with its grave consequences affects the periodontal therapeutic decision making in chronic HT or stroma lymphomatora is the most common autoimmune thyroid disease with 10 percent of total population resulting in thyroid failure. Hence this study emphasis the need to investigate and analyze the T3 & T4 & TSH levels in HT and Corelate with severity of periodontal disease. To obtain a standardized protocol for diagnosis and management of periodontal disease in hashimotos thyroiditis females. Materials and methods: A total of 30 female patients were randomly selected during their laboratory examination of thyroid hormone assessment. Statistical analysis: was performed using Microsoft excel 2003 and statistics 5.0. Result: The mean PI showed a weak positive correlation with T3, T4 & TSH. Out of 30 patients, with mean TSH levels of 8.82 mg/dl showed a positive correlation with clinical signs of gingivitis.