The toxicity of a substance can be affected by many different factors such as the route by which the substance was introduced or administered (whether through application, contact with the skin, ingestion, inhalation, or direct injection), time or duration of exposure (short or long-term encounter) and the number of Exposure times (single doses or multiple doses over time), the physical form of the toxin (solid, liquid or gas), an individual’s genetic makeup and general health, among many other factors. There are many terms used to describe these factors, such as acute exposure and chronic exposure: Acute exposure: It means the single exposure to a toxic substance that may cause severe biological damage or even death, and acute exposure is usually characterized by the duration of exposure does not exceed one day. Chronic exposure: Continuous exposure to a toxin occurs over a long period of time, often measured in months or years, and can cause irreversible side effects. Toxic as in pregnant women or those suffering from certain diseases, and when evaluating a new and previously unstudied chemical, it can be compared with the other studied substances if it is believed that the two substances are very similar, but with the addition of a safety factor of 10 to take into account the possible differences between them, although the differences do not require in Usually such a level of safety is, because this approach is a very conservative approximation to allow it to be applied to a wide range of materials.