This study investigated psycho-demographic variables and domestic role of married female teachers in public senior secondary school in Rivers State. Three research questions and three corresponding hypotheses guided the study. The study adopted mixed research design involving correlational and ex-post facto research designs. The population for the study comprised of all the 5,437 married female teachers in senior public secondary school in Rivers State. A sample size of 400 married female teachers was drawn from the population through stratified proportionate random sampling technique. Two instruments titled “Psycho-Demographic Variables Scale” (PDVS) and “Domestic Role of Married Female Teachers’ Scale” (DRMFTS) were used for data collection. Face and content validates of the instruments were ensired by three experts. Cronbach Alpha reliability method was used to established the reliability coefficients of the PDVS to be 0.57 and DRMFTS 0.69 respectively. Data collected were analyzed using Pearson product moment correlation fore research question, while the critical probability value of the corresponding hypothesis 1 were subjected at 0.05 alpha level of significance. Mean, standard deviation were used to answer research questions 2 and 3 and their corresponding hypotheses were tested with One-way ANOVA at 0.05 Alpha level of significance. It was found that there is significant positive relationship between self-esteem and domestic role of married female teachers in public senior secondary school in Rivers State, there is significant influence of educational qualification on domestic role of married female teachers in public senior secondary school in Rivers State and there is significant influence of levels of income on domestic role of married female teachers in public senior secondary school in Rivers State. Based on the findings conclusion, recommendations and implications for counselling were made.