As a special form of cultural transmission, English sitcom has won the favor of audiences all over the world with its humorous language. However, limited by language and culture, how to translate the verbal humor of English sitcom has become a difficult problem in translation field. In order to give Chinese audiences a better experience, domestication and foreignization, two important translation strategies, are often applied to subtitle translation of English sitcoms. In the process of subtitle translation of Friends, domestication and foreignization are complementary rather than antagonistic. This paper selects some subtitle clips from Friends to discuss the application of domestication and foreignization in The Chinese translation of English subtitle. This paper mainly explains the characteristics, principles and strategies of subtitle translation in sitcoms, and studies and summarizes the influence of subtitle translation on translators.