Abstract: Background: Dental implant disease described as Peri-implantitis is bacterial inflammation of the implant surrounded soft and hard tissue that can lead to bone loss and eventual failure of the implant fixture. Several protocols have been introduced to treat implantitis including the use of systemic and local antibiotics in addition to bone grafting in advanced cases. Although the treatment outcome is effective in the early to moderate cases its unpredictable in cases with severe bone loss. Human placental tissue has been introduced in medicine for the treatment of burns and ophthalmic disease around the turn of the century. In dentistry, the placental derived tissue has demonstrated a promising and effective role in the treatment of soft and hard tissue deficiencies within the oral cavity. Methods: In this report, the Amnion-Chorion membrane of the placenta was used in strips and mixed with the bone graft material after treatment of the contaminated implant surface. Results and Conclusion: The results showed substantial bone fill around the implant with uneventful healing of the surrounding mucosal tissue. This technique can serve as a predictable protocol for the treatment of advanced dental implant disease.