Introduction: Subclinical hypothyroidism (ScH) is an endocrine alteration that is related to cardiovascular risk factors, including those categorized as components of the Metabolic Syndrome (MS). However, findings in prior reports regarding an association between these alterations are inconsistent. Metabolic syndrome is now considered as global epidemic and for last few decades MetS is highly prevalent in Bangladesh. Objective: To determine the metabolic syndrome is associated with subclinical hypothyroidism. Materials & Methods: The present case-control study was conducted in the Department of Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh over a period of one year between January 2020 to February 2021. Patients of metabolic syndrome were considered as case, while apparently healthy individuals (having no hypertension, central obesity or dyslipidaemia) were taken as control. Metabolic syndrome was defined as having at least three criteria out of five criteria, as recommended by NCEP: ATPIII Diagnostic Criteria for Metabolic Syndrome, while subclinical hypothyroidismwas defined, when TSH ranges from 4-20 mU/L with normal FT3 and FT4. During the study period, while friends and relatives of cases of similar age and sex were selected as control. Results: A total of 71 cases and 71 controls were consecutively included in the study. In the present study out of 71 cases 49(69.01%) had central obesity (waist circumference > 90 cm for male and > 80 cm for female), 57(81.4%) had raised triglycerides (TG ≥ 150 mg/dl), 61(87.1%) had raised blood pressure (≥130/85), 60(84.51%) had hyperglycemia (fasting blood glucose ≥ 100 mg/dl) and only 12(16.90%) had reduced HDL (< 40 mg/dl for male and < 50 mg/dl for female) three factors, namely subclinical hypothyroidism , BMI and socioeconomic status were observed to be significantly associated with metabolic syndrome in univariate analysis. After adjustment by binary logistic regression analysis, all these three variables remained to be significantly associated with metabolic syndrome with risk of having the condition being 2.3(95% CI = 0.9–5.8) times more in patients with subclinical hypothyroidism, 2.3(95% CI = 1.4–8.1) times higher in overweight/obese individuals and 2.8(95% CI = 1.3–5.8) times higher in affluent socioeconomic class (p=0.038, p=0.007 and p=0.006 respectively). The present study revealed that subclinical hypothyroidism significantly associated with MetS. Subclinical hypothyroidism carries more than 2-fold higher risk of having MetS.Conclusion: The study found that factors, namely subclinical hypothyroidism, BMI and socioeconomic status to be significantly associated with metabolic syndrome in univariate analysis. After adjustment by binary logistic regression analyses, patients of metabolic syndrome carry more than 2.7-fold higher risk of having subclinical hypothyroidism.