Background: Tibia being a large bone in humans anatomically is always prone to fracture in cases of trauma owing to its capacity to bear load the recovery can be complicated easily by instability, delayed recovery, and long illness. Tibial shaft fractures are often the result of high-energy injuries in younger peoples. Intramedullary nailing is one widely used form of fixation with excellent results. Objective: To assess the functionality in tibial shaft fracture using intramedullary interlocking nailing technique in patients coming with tibial shaft fracture. Methodology: A prospective observational study was conducted in the Department of ortho & Spine surgery, National Institute of Traumatology & Orthopaedic Rehabilitation (NITOR), Dhaka, Bangladesh over a period of one year between June 2018 to July 2020. A total of 59 participants were evaluated who met the inclusion criterion for the study of which data for 56 were available for analysis as 3 patients didn’t completed the follow up. They were included only after satisfying the laid down inclusion criterion while after performing routine procedures they were given the treatment of intramedullary interlocking nailing if indicated. Data collected on excel sheets were analyzed using SPSS for tests of association and measures of central tendency. Results: 56 participants were there who were offered the treatment of intramedullary nailing with interlocking nailing majority of them were males from BPL. Most of the injury was of type A from Motor vehicle accidents involving proximal shaft. John Wruh’s criterion was used to assess the functional outcomes with 47% having excellent results. Only 3 (5%) of the patients had poor results. Conclusion: Interlocking Intramedullary nailing for tibial shaft fractures is an excellent method of surgical management. Intramedullary nailing decreases the occurrence of complications such as infection thus by decreasing the time to recover in patients receiving such injuries.