The harms arising from substances/drugs uses and misuse are diverse and vary based on the substance used and the pattern and context of their use, but it is well proven that their use represents a major public health threat. Therefore, the objective of this paper was to determine the commonly use drugs/ substances, places of taking drugs, influencers, administration methods, and specific substance use among youths in Sokoto, Nigeria. Cross-sectional descriptive survey was used to cover some selected schooling and non-schooling youths in Sokoto state of Nigeria. . A questionnaire was used to collect data from a sample size of 60 respondent’s drug users, with the help of voluntary research assistants after a pilot study. The data was analyzed using thematic content analysis. Descriptive statistical values were calculated. Commonly use drugs/ substances by the youths in the state are: cassette water/Ruwan Casette, Toilet odour/ Nail water, wewe, burkutu, codein, morphine, LSD, petrol, Sholisho, Zaren kaset, nail water, D5, valium, syrup, Sigari. Methods of administration include: smoking, chewing, eating, drinking, swallowing, and sniffing. Peer/social pressure is the main influencer to drugs.