Stein-Leventhal syndrome (Polycystic ovaries syndrome), represent one of the major obstacles facing reproductive medicine researchers, because there is no information about the etiology of it, and that made them fail to draw smile on faces of millions of women around the world, who are suffering from it. Scientists said that it is attributed to genetic and environmental factors, and we hypothesized that it was caused by environmental pollution by dioxins (specifically heavy metals), which disturb aryl hydrocarbon receptor and that lead to disturbing of nuclear receptors and then express genes which lead to hormonal, metabolic and immunological abnormalities appear in PCOS patients. And fortunately this hypothesis supports our hypothesis about the etiology of COVID-19 and its variants, clinically and epidemiologically. PCOS can be transmitted transmammry, sexually from Dixon exposed male partners, and due to direct exposure to Dixon either via explosion or by excessive use of makeup .Experimental studies is required to test our hypothesis.