This study assessed the effects of climate change on fluted pumpkin production and mitigation/adaptation measures used by farmers in Itu District, Itu LGA of Akwa Ibom State in Southern Nigeria. Random sampling and purposive sampling techniques were adopted for the selection of respondents comprising 100 fluted pumpkin farmers; 10 from each of the 10 communities that make up Itu District. FGD was used to elicit data on effects of climate change on fluted pumpkin production and climate change mitigation/adaptation measures. The study found the farmers perceived low yield of fluted pumpkin, loss of soil fertility, erosion, and declining family income as the major effects of climate change on fluted pumpkin production. Combination of fluted pumpkin production with other income generating activities was also found to be the most widely used mitigation/adaptation measure. The study recommended government effort through agricultural extension services and agricultural development programmes to mitigate/adapt climate change impacts by adopting improved varieties of fluted pumpkin seedlings, agricultural diversification, accurate and timely weather forecasting, use of cover crops, and disseminating up-to-date climate change information. Formation of co-operative societies among farmers to pool resources to fight the effects of climate change was also encouraged.