With the acceleration of economic globalization in recent years, china has assessed the situation and joined the pace of integration into the world financial system. With the continuous progress of global economy and the continuous improvement of corporate business needs, internal control plays an increasingly important role in the survival and development of enterprises. Successful internal control is conducive to the company's expansion of production scale, improvement of the core competitiveness of the industry, more effective operation of the company, and even a successful listing of the company. Therefore, the study of internal control is very necessary. This paper first describes the background of internal control in china, and then summarizes the contents of the five elements of internal control. Through the contents of the five elements, it analyzes the hardships of the listing of guangdong marus biotechnology co., ltd. (hereinafter referred to as marus), the protagonist of this paper, and the major reasons for the failure of listing.in addition, it is necessary to find relevant remedial measures to help marumi get out of the predicament of ipo failure, and what kind of preventive measures to prevent ipo failure for enterprises that want to go public based on the five elements of internal control. Finally, the conclusion of the study gives us some enlightenment. The purpose of this paper is to make an in-depth analysis of various problems arising from the failure of marumi stock listing from the perspective of internal control and give constructive suggestions, so as to inspire various unlisted enterprises on how to improve their internal control and prevent ipo failure from the perspective of internal control.