Background: Inflammation is a biological response to a series of chemical reactions whose major function is protection from infection and the resolution of tissue damage caused by injury. There are several mediators released during the process of inflammation. Flavonoids are universal in photosynthesizing cells and are often found in vegetables, fruit, nuts, seeds, stems, tea, flowers, honey and wine preparations. This class of natural products is becoming the subject of anti-infective research, and many groups have isolated and identified the structures of flavonoids possessing, antiviral, antifungal antibacterial activity and anti-inflammatory activity. This study has been carried out to rationally design quercetin was assayed for anti-inflammatory potential by using in-silico molecular docking approach. Methods: Molecular docking of Phosphodiesterase 4 (PDE4) with quercetin was carried out by AutoDock. Result: The molecular docking result revealed that quercetin showed encouraging docking score. The docking score found to be -7.67 kcal mol–1 respectively.