E-commerce is talked about a lot, but a deeper understanding of its applications to apply in practice in businesses to contribute to great economic efficiency is an issue that needs to be discussed more. Artificial Intelligence (AI) is the technology that will have the maximum impact on e-commerce in the coming years. According to an IBM report, more than 90% of productive organizations are considering enterprise-level AI adoption. In addition, a Gartner report predicts that 37% of organizations have implemented AI in some form. From optimizing inventory levels to intelligent fraud management, AI is doing more than sending personalized product recommendations to customers. Based on the study of related concepts and the current situation of e-commerce enterprises in Ho Chi Minh City, this study wants to analyze the impacts of artificial intelligence on the management and business processes of e-commerce enterprises businesses in Ho Chi Minh City, thereby proposing solutions to improve the e-commerce business of enterprises in Ho Chi Minh City.