COVID-19 or SARS-COV-2 is a serious viral illness that has spread all over the world, this disease belongs to the group of coronaviruses. Like other coronaviruses it was transmitted to humans by animals, which is said to be an outbreak from a fish market in Wuhan (China) in December 2019. World Health Organization (WHO) has reported that COVID-19 is a pandemic on March 11, 2020 [2]. For the management of spreading of this disease, some countries forced a complete lockdown. Social distancing, hand hygiene, and isolation were considered largely effective for COVID-19 control [2]. Many medications have been reported for the treatment of Covid-19 disease. One of these medications is hydroxychloroquine/chloroquine which has gained a lot of popularity during the pandemic. This study aims to review the effect of HCQ and CQ on cardiovascular patients with COVID-19 and estimate the potential adverse effects.