Background: Chronic obstructive pulmonary disease, or COPD, refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema and chronic bronchitis. Patients with COPD are at increased risk of developing heart disease, lung cancer and a variety of other conditions. Although COPD is mostly a chronic disease, a substantial number of patients experience exacerbations that are related to a significantly worse survival result, especially with abnormal serum electrolyte level. Objectives: The aim of this study is to assess the Serum Electrolytes and Oxygen saturation in acute exacerbation of chronic obstructive pulmonary disease patients. Methods: This is an observational study. The study was carried out in the admitted patient’s Department of Medicine, Netrokona Medical College and hospital, Bangladesh. The duration of the study from October 2019 to March 2021. Results: This study shows that the according to age of 120 Patients aged 40 to 69 years. Here according to Age distribution, 6(5%) were <40 years, 8(6.66%) were 40- 49 years, 21(17.5%) were 50-59 years, 48(40%) were 60-69 years and 37 (30.83%) were ≥ 70 years. Distribution of the study according to sex of 120 Patients aged 40 to 69 years. According to gender 102(85%) were Male, 18(15%) were Female. According to Parameter, the Mean±SD of Serum Sodium, Serum Potassium, O2 Flow (L/min), pH, PaCO2 (mmHg), HCO3 (mmol/L), SpO2 (%) and Respiratory Rate (Breaths/min) were 131±5.07, 3.31±0.33, 0.6±0.4, 7.43±0.02, 40±4, 27±2, 90±1.2 and 22±3 respectfully. Conclusions: The levels of parameters should be measured and corrected during AECOPD treatment to decrease mortality and the correct use of supplemental oxygen therapy during exacerbations of COPD is an impor¬tant factor that can strongly influence outcomes.