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Global Academic Journal of Pharmacy and Drug Research
Volume-4 | Issue-05
Original Research Article
Design and Evaluation of Extended-Release Matrix Tablet of Tramadol Hydrochloride
Neha, Jitender K Malik
Published : Dec. 29, 2022
DOI : 10.36348/gajpdr.2022.v04i05.001
Abstract
The impartial concerning this study was to cultivate extended-release matrix pellet of Tramadol hydrochloride using various combinations of hydrophilic polymers (HPMC, Carbopol, Xanthum Gum). The form tablets were prepared by direct compression method. The pre and post compression description of blend and tablet were judged. The in-vitro dissolution studies revealed that the blend of HPMC and Carbopol in different aggregation showed hinder release of 63% at the end of 12th hour and in addition to 94.24% at the end of 24th moment, thereby appearance good release pattern necessary for ER tablet and shown good kinetic release connected of diffusion and deterioration. Hence hydrophilic polymer HPMC and Carbopol was found to extended release of very water-soluble drug, Tramadol hydrochloride.

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