Vaccine development platform technologies that can produce a wide range of vaccines are emerging. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic which has induced unprecedented ramifications, severely affecting our society due to the long incubation time, unpredictably high prevalence and lack of effective vaccines. Safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases DNA technology can simplify the complexity of manufacturing and facilitate consistent production of large quantities of antigen. Messenger RNA (mRNA)-based vaccines have shown promise against infectious diseases and several types of cancer in the last two decades.