Abstract: Different approaches have been applied to the criticism of literary works each manifesting special areas of literary genres, each highlighting the works’ merits and demerits in its own way. This paper has surveyed the application of reader-response theory to the interpretation of To Kill a Mocking Bird novel and the possible impact it may have on the interpretation of the work and development of the interpretive power of to-be-teachers’ students at undergraduate setting. Deploying the qualitative research design, the paper tried to answer the research questions of the amount of impact it had on the students’ historical and literary knowledge of the country whose language teaching would be their future profession. The analysis of the collected reader responses revealed that this approach would be of ease of administration on the part of the instructors and would enhance the learners’ power of interpretation, as well as their knowledge of historical events of the English language and literature.