A potentially fatal illness known as toxic epidermal necrolysis (TEN) is marked by severe exfoliation of the mucous membrane and epidermis, which can lead to sepsis and death. In our case we observed a female, who was admitted to tertiary care as she developed low grade, intermittent fever accompanied with body ache and joint pain. Fever was not accompanied with chills and rigors. She consulted a local doctor for the same and was suspected a case of Chikungunya. She was prescribed oral medications [Tab. HCQ (200mg) and Tab. Naproxen (500mg)]. Later on, she developed itching and red colored skin lesions with burning sensation. We concluded that appropriate counselling can lead to successful outcome of the treatment. By doing that severe adverse reactions can be prevented.