The following is a clinical case of a screw-retained prosthesis on two implants with different designs and manufacturers. A 73-year-old man visited the dentist in January 2023 to rehabilitate the edentulous right area of the mandible. In December 2018 another dentist placed implants (Biohorizons, Madrid. Spain) in positions 45 and 46 with a metal-porcelain bridge over both. In 2022 he lost implant 45 (Biohorizons tapered internal 3.8 x 9) and with it also the bridge, although he still had implant 46 (Biohorizons tapered short 4.6 x 7.5). On the day of surgery, a simple opening flap was performed and drills were used sequentially until a 4 x 8 mm Galimplant IPX implant (Sarria, Spain) was placed in position 45. After a period of four months, the impression abutments of implants 46 and 45 were attached with dental floss and flowable composite, and an open-tray impression was taken. One week later, the screwed metal-porcelain fixed prosthesis was placed on both implants. It is difficult to find bibliographic information about fixed prostheses on implants manufactured by different companies and placed in the same patient. The placement of a prosthesis on two implants from different manufacturers is not a complication, but rather an unscheduled inconvenience. The clinical case presented allows us to point out that a fixed prosthesis on implants from different manufacturers can give excellent results.