The treatment options that have an impact on quality of life include dialysis. This qualitative study aims to shed light on how hemodialysis patients see their experiences with depression and other psychological issues. End-stage renal illness is a global issue that affects many people in various nations and is treated with either transplantation or hemodialysis. The purpose of this study is to evaluate how hemodialysis would affect patients' psychological states and how these individuals will change in response to hemodialysis. A cross-sectional study of 120 people were chosen, 75 of whom were men and 45 of whom were women. Between December 2022 and March 2023, it was carried out at the kidney foundation hospital and research institute in Bangladesh. Information gathering based on patient interviews conducted by our research team and the unit at the kidney foundation hospital. Themes that emerged from the analysis point to hemodialysis, propensity was depression. Additionally, the results show that the majority of them have diabetic nephropathy and are in a terrible to moderate psychological state, as seen by their inability to communicate and their lack of response to family members' and doctors' instructions. Among all the patients 15% patients have got up with hepatitis and rest of time were clear from hepatitis.