The Fourth Industrial Revolution is bringing about major transformations: a new order is emerging, new ecosystems, new business models are emerging and creating challenges as well as opportunities for every individual, and every business. Business competition in the digital age is increasingly intense, requiring constant innovation and improve to adapt to changing customers and the economy. Digital transformation is a requirement for emerging economies like Vietnam. Retail business is detailed, specific, and complex. Retailers need to find ways to reduce shipping costs and keep improving their inventory position. Retailers also need to be aware of enhancing value-added services to customers, cutting the cost of manpower, and running while expanding sales channels. So the application of technology to business and retail management is essential nowadays. In this article, the author discusses the reality of the Vietnam retail industry in its approach to technology, opportunities, and challenges, suggesting several solutions to enhance the digital transformation capacity of retail enterprises in the context of digital transition.