Objective: The project aimed to call to mind the leveraging of health management and information systems among healthcare workers at Kenyatta National Hospital, Kenya. Design Setting: The investigation deployed a cross-sectional study. Subjects or Participants: A sample total of 263 respondents was calculated using the Krecie and Morgan formula for the quantitative study. A strict inclusion criterion was followed to select the respondents from all trained health personnel in Kenyatta National Hospital. The study utilized an interview schedule. Data were analyzed using SPSS version 21 while qualitative data was analyzed on themes developed. Data presentation was in the form of quantitative statistics such as frequency distribution, percentages and tables. Qualitative results were presented in verbatim form. Results: A total of 263 respondents were engaged in the quantitative study. The study utilized a questionnaire and a key informant interview guide. Before processing quantitative data, data was cleaned, coded and keyed into MS Excel database computer and analyzed using SPSS version 21. Descriptive statistics were used to describe measures of central tendency and dispersion. Findings were presented using frequency distributions and summary tables. Associations between predictor and outcome variables were run through Correlational statistics. Of the 263 respondents, 199 (74.8%) had a positive attitude and 27 (10.2%) had a negative attitude while, 40 (15.0%) were neutral regarding the concept that change has brought about better, more effective and efficient healthcare services delivery at KNH. HMIS methods have been harmonized and standardized exhibited a strong positive correlation with HMIS implementation (r = 0.6767, p < 0.01), significantly indicating that the implementation success was associated with the harmonization and standardization of HMIS methods. Conclusion: Given the massive return in terms of avoiding future economic and social losses, investing in a resilient health system that provides high-quality essential health services should not be considered a luxury anymore, but as the foundation of social, economic and political stability.