Water is an indispensable natural resource and have remained a cause for worry in both urban and rural communities in Nigeria. A total of 15 samples were obtained from different groundwater sources in Wamakko, LGA, Sokoto State, Nigeria. Physicochemical and microbiological analysis were performed on the samples to ascertain changes in the proxies and presence of indicator organisms in the water samples. The pH of the groundwater samples obtained from point 6 was observed to have a pH of 5.6 this index was far below WHO /NIS/ NAFDAC specification for potable water. Total dissolved solids (TDS) of the groundwater samples ranged from 57.6mg/L to 529.96 mg/L while samples obtained from sampling point 7 had the lowest concentration values. The concentration of phosphates in the groundwater was observed to range from 0.16±0.01a to 5.21±0.12h mg/L. Pearson Correlation showed strong correlation between turbidity and BOD of groundwater at r=0.800, Salinity and hardness of the groundwater with a correlation coefficient of 0.88 at p-value < 0.0. The samples obtained from point 6 were observed to have a fecal coliform count of 6 MPN/100ml and 40MPN/100ml for total coliform The samples obtained from samples obtained from points 1 and 4 had a bacterial load of 1.1x105CFU/ml while the samples obtained from point 14 had a bacterial load of 1.3 x104 CFU/ml The microbial diversity ascertained by the biochemical evaluation showed that the bacterial flora obtained from point 14 were Pseudomonas, Salmonella sp., E. coli and Enterobacter sp. The groundwater sources were tained by the anthropogenic activities in the Wamakko LGA as this have shown a shift in the microbiological qualities of the water samples. There is need for Sokoto State Government to look into the remote cause of the water pollution and come up with a risk-oriented strategies to stem these tides.