This study examines the influence of E-procurement systems for organisational performance of manufacturing firms in Port Harcourt. This study adopted a descriptive survey research design as the study seek to determine the influence of E-procurement systems on performance of manufacturing firms in Port Harcourt. The population of the study consisted of 11 firms in Port Harcourt. The study adopted a census population. 3Managers were selected from each firm multiplied 11 firms give us a total of 33 respondents under study. Structured questionnaire instrument title” the E-procurement systems for performance questionnaire “was developed on five-point likert scale. The primary data for this study were generated through questionnaire and hypotheses were tested using regression analysis on SPSS. The study revealed that distribution planning significantly influences profitability of manufacturing firms in Port Harcourt, distribution planning significantly influences resources utilization of manufacturing firms in Port Harcourt, route optimization significantly influences profitability of manufacturing firms in Port Harcourt, route optimization significantly influences resources utilization of manufacturing firms in Port Harcourt. The study concluded that E-procurement systems significantly influences performance of manufacturing firms in Port Harcourt. The study recommended among others that manufacturing firms in Port Harcourt should invest in advanced transportation modeling software to optimize their distribution networks.