Abstract: Background: On 31 December 2019, the Coronavirus Disease 2019 (COVID-19) emerged in China, and soon declared a pandemic by the World Health Organization. Afghanistan reported its first imported case in late February 2020. The aim of this study was to review and describe the epidemiological pattern of cases of COVID-19 during the first three months period of its spread in Afghanistan. Methodology: We conducted a descriptive epidemiological study to describe the cases and deaths due to COVID-19 in terms of time, place and person. Data were extracted from District Health Information Software 2 (DHIS2) databases developed and used by Ministry of Public Health between February 24 to June 04, 2020. The frequency of cases of COVID-19 infection and percentage of resulting mortality and case fatality rate were calculated and categorized by sex, age group, and provinces. Measures taken in response to pandemic were reported as well. Results: The first suspected case of COVID-19 was imported from Iran to Hirat province in Western Afghanistan, and confirmed by lab on 24 February in Afghanistan. On 22 March, the first official death due to COVID-19 was announced in Balkh, a Northern province and the two new cases in Kabul Province were announced both foreign diplomats After more than three months on 04 June totally 18.969 cases including 309 deaths were reported officially by Ministry of Public Health. Totally 45,139 samples have been tested by PCR and 42% were positive. Kabul, Hirat, Kandahar, Balkh and Paktia are the top high infected among 34 provinces. Average age of infected are 37 years with minimum of one year and maximum 100 years. Of total cases, 74% of new cases and 81% of deaths were males. Majority of cases (53%) were young in age group of 20 to 40 years. Majority of deaths occurred in age group of 50 years and older while there was just one case of death (2%) in age group of less than 30 years. Out of all cases, 1903 (13.7%) were hospitalized of whom 74% were males. Until now, 872 healthcare workers are infected of whom 13 are dead. Recovery rate is 9% and case fatality ratio is 1.63%. Conclusion: Like many developing countries with existing challenges of insecurity, poverty, and political uncertainty, Afghanistan has been burdened with epidemic of COVID-19 since February 2020. Higher morbidity was recorded in young population while increased rates of mortality were recorded in older groups. Further epidemiological studies are required to determine the various aspects of the disease burden in the country including risk factors for infection and short and long-term health outcomes of COVID-19 in Afghanistan.