Background and Aim: Kidney disease represents a growing global challenge that disproportionately impacts impoverished, vulnerable, and marginalized communities, leading to significant individual, healthcare, and societal expenses. The current investigation focused on assessment of the role of zingiber officinale aqueous ginger extract (AGE) on induced kidney dysfunctions in male rats as a model. Methods: This study was performed on 40 male rats divided into 4 groups each group included 10 white Albino rats. CCl4 was intraperitoneal (i.p.) injected for 3 days and following administration of aqueous ginger extract (AKE) (250 and 500 mg/kg/b.w. for 15 days as period of this experiment). At the end of this study, biochemical markers related to kidney dysfuntions such as, serum creatinine (CR), uric acid (UA), total antioxidant capacity (TAO-C), and the malondialdehyde (MDA) as antioxidant and oxidative stress markers were assessed by spectrophotometric methods. Results: The results of this study were showing CR (mg/dl) and UA (mg/dl) levels were significantly elevated in the T2 group as negative control group in comparison with the T1 as control group (p<0.05). UA (mg/dl) levels were found significant decrease in T4 and T3 groups in compare with T2 and T1. The results shown significant increase in TAO-C in T4 and T3 compare to T2, also TAO-C (U/ml) levels were found significant decrease in T2 group in compare with T1. Conclusion: This study suggested that a significant protective action of AGE on CCl4-induced kidney damage in the male rats model.