Introduction: The co-occurrence of diabetes and COVID-19 infection poses a significant medical challenge due to the increased risk of serious complications. Infection with SARS-CoV-2, the virus responsible for COVID-19, exacerbates these risks because of the systemic inflammation it causes and the direct and indirect effects of the virus on the cardiovascular system. Objective: The aim of this study was to explore cardiovascular risks in diabetic patients testing positive for COVID-19 in Pointe-Noire, Republic of Congo. Methods: We recruited a total of 206 participants for this study. Biomarkers were quantified from blood samples and sars cov-2 virus was identified using the PCR technique on nasopharyngeal swabs. Results: Analysis of our data shows that the following biological parameters are evidence of cardiovascular complications ESR: OR 1.91(1.84-1.97) p<0.001 DDI: OR 1.01(1.01-1.01) p<0.001, APTT: OR 1.67(1.33-2.09) p<0.001, TG/hdl: OR 1.78(1.48-2.13) p<0.001, CK-MB: OR 1.37(1.17-1.59) p<0.001. There was also a strong correlation between AIP and TG (r =0.86, p<0.001) and inversely with HDL (r= -0.56, p<0.0001). A strong association between AC with LDL (r=0.79, p<0.001) and TC (r=0.68, p<0.001). A strong inverse linear correlation of CRR with HDL (r= -0.79, p<0.001) and positive with TC (r=0.53, p<0.001). A strong correlation coefficient of between CPI with HDL (r=0.69, p<0.001) and negative with CT (r= -0.46, p<0.001) and, an inverse relationship with HbA1c(r= -0.22). Conclusion: The results of our study show that COVID-19 in T2DM can cause cardiovascular complications or deterioration of coexisting cardiovascular disease by direct or indirect mechanisms.