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Global Academic Journal of Pharmacy and Drug Research
Volume-7 | Issue-01
Original Research Article
Deciphering of Anti-Alopecia Activity of Polyphenol from Beta vulgaris Root against 5α-reductase: Molecular Insight
Komal Devi, Jitender K Malik, Gyan Singh
Published : Feb. 24, 2025
DOI : https://doi.org/10.36348/gajpdr.2025.v07i01.002
Abstract
Background: Androgenetic alopecia (AGA) is the predominant form of nonscarring alopecia, characterized by a progressive and predictable loss of hair. Androgenetic alopecia (AGA) is influenced by genetic susceptibility and heightened follicular sensitivity to androgens, predominantly in males, resulting in the gradual transformation of scalp terminal hair into vellus hair. Despite its great prevalence, it is not lethal but may exert a significant emotional influence, particularly on females and younger boys. Substantial progress has been achieved in comprehending the epidemiology and pathophysiology of AGA; nonetheless, only two medications have received FDA approval: finasteride and minoxidil. Extended administration of these medications is essential for improved therapeutic response. Nonetheless, this results in inadequate medication adherence and negative consequences from prolonged use, such as the "post-finasteride syndrome," which endures after discontinuation of the medicine. Consequently, research is required to identify more effective alternative treatments for AGA that exhibit less adverse effects. Prior study demonstrated the effectiveness of polyphenols in addressing metabolic disorders. The root of Beta vulgaris was considered for the current inquiry. Purpose: Current work was designed to check efficacy of root extract and their bioactive for anti-alopecic potential. Methodology: Scientific validation of the current investigation was done by computational based molecular docking study of lead molecules of Beta vulgaris root against 5α-reducatase (SRD5As) enzyme. Result: The root of Beta vulgaris has been identified as an effective anti-alopecic drug, with its lead compounds, 4-picoline and Betalain, demonstrating effective binding to the target protein 5α-reductase (SRD5As) with binding energies of -4.09 and -7.93 kcal/mol, respectively. Conclusion: The findings indicated that each selected lead chemical for additional investigation shown significant inhibitory activity against 5'-reductase (SRD5 As), hence revealing its anti-alopecic potential.

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