Abstract: Public-private partnerships (PPPs) have emerged as a critical strategy for improving healthcare service delivery by leveraging the strengths of both the public and private sectors. This study examines the role of technology, business strategies, and governance structures in optimizing healthcare PPPs, addressing existing gaps such as regulatory inefficiencies, financial sustainability, and scalability challenges. Employing a mixed-methods approach, the research integrates qualitative and quantitative data from interviews, surveys, and case studies to assess the effectiveness of various PPP models. Findings indicate that digital health innovations, risk-sharing financial frameworks, and transparent governance mechanisms significantly enhance PPP performance. However, challenges such as policy inconsistencies, misaligned stakeholder objectives, and short-term financial agreements hinder their long-term sustainability. The study provides policy recommendations for regulatory harmonization, performance-based financing, and strategic digital integration, ensuring more efficient and equitable healthcare partnerships. It also proposes a scalable best-practices framework adaptable across different healthcare settings. Future research should focus on sector-specific PPP models, cross-border regulatory standardization, and pandemic preparedness strategies. By addressing these critical issues, this study contributes to the sustainable transformation of PPPs, enhancing healthcare accessibility, affordability, and efficiency worldwide.