Abstract: Multinational enterprises (MNEs) operate in an increasingly complex regulatory environment, requiring strategic compliance oversight to mitigate risks, ensure operational integrity, and uphold corporate governance. This study explores the challenges and best practices in multinational compliance oversight, emphasizing the need for adaptive compliance frameworks that balance global regulatory standards with local jurisdictional requirements. The research highlights the role of sustainability governance and the integration of environmental, social, and governance (ESG) principles in compliance strategies. Additionally, it examines how emerging technologies such as artificial intelligence (AI), blockchain, and big data analytics enhance compliance monitoring, fraud detection, and risk assessment. The study employs a qualitative approach, incorporating case study analysis, expert interviews, and comparative benchmarking to assess compliance effectiveness across industries. The expected findings suggest that proactive compliance models, sustainability-driven governance, and technological innovation contribute to improved regulatory adherence and litigation risk mitigation. The research concludes with strategic recommendations for MNEs to strengthen compliance frameworks, enhance regulatory engagement, and integrate digital transformation in compliance oversight. This study provides valuable insights into evolving compliance challenges, offering a comprehensive model for corporate leaders, policymakers, and regulatory bodies to optimize compliance management in global business operations.