Diabetic foot ulcers (DFUs) are among the most serious complications of diabetes mellitus, greatly reducing patients’ quality of life and frequently leading to chronic infections and possible limb amputation. DFUs arise from a multifaceted interaction involving peripheral neuropathy, insufficient blood flow, and immune system impairments. This research focuses on examining specific cytokines and hematological indicators in individuals with DFUs to gain deeper insight into the reasons behind impaired wound healing. The study as well as complete blood count (CBC) C-reactive protein (CRP), 90participants took part in the study, categorized into three groups: 30 diabetic patients with DFUs, 30 diabetic patients without foot ulcers, and 30 healthy individuals. Those who reviewed the Diabetes Centers at Al-Hashimiyah General Hospital and Al-Qassim General Hospital in Babylon Province between September 2024 and February 2025 were included in the study. Each patient was diagnosed with DFU by a specialist, with confirmation provided through X-ray imaging. Blood samples were collected CBC. Biochemical tests were carried out to measure CRP. Statistical analysis was performed to compare findings across the. The comparison of some blood parameters (WBC, RBC and platelets) "A comparative analysis was carried out between the patient groups and the healthy controls. The mean white blood cell (WBC) count was 7.48 ± 2.21 in patients with ulcers, 8.41 ± 2.18 in diabetic (DM) patients, and 7.25 ± 2.01 in the control group. Despite DM patients showing higher average WBC counts than the other groups, the difference between ulcer and DM patients was not statistically significant (P > 0.05). For red blood cell (RBC) counts, the averages were 3.93 ± 0.81 for ulcer patients, 4.00 ± 0.76 for DM patients, and 4.38 ± 0.41 in the control group. Although both patient groups had lower RBC counts compared to the controls, the difference between ulcer and DM patients was again not statistically significant (P > 0.05). Furthermore, platelet counts did not significantly differ between patients and healthy individuals (P > 0.05). The mean C-reactive protein (CRP) levels were 128.4 ± 13.3 in ulcer patients, 47.78 ± 12.7 in DM patients, and 7.03 ± 1.3 in the healthy controls. Mean levels of C-reactive protein (CRP) were and the difference was significant (P< 0.05) in Ulcer patients, DM patients and healthy control group. We conclude from our current study a chronic inflammatory environment in DFU patients WBC count alone may not be a reliable marker for systemic inflammation or disease severity in diabetic individuals. More accurate and specific biomarkers such as C-reactive protein (CRP) are necessary for a precise evaluation of inflammatory status Elevated CRP levels highlight the underlying metabolic challenges that impair wound healing. The reduced RBC levels may indicate mild anemia, which impairs erythropoietin production a platelet levels could be attributed to small sample size or considerable inter-individual variability these biomarkers point to a complex interplay of immune and metabolic dysfunction, underscoring the need for comprehensive treatment strategies that include blood glucose control, immune regulation, and angiogenesis support. The study promotes the use of these biomarkers for diagnostic purposes.