Lifestyle diseases, or non-communicable diseases (NCDs), represent a significant global health burden. These diseases are primarily associated with modifiable behavioural risk factors, including poor dietary habits, sedentary lifestyles, and the consumption of alcohol and tobacco. Common lifestyle-related conditions include diabetes mellitus, hypertension, and obesity. In the Unani system of medicine, health is maintained through the balance of six essential factors (Asbāb Sitta Ḍarūriyya), among which Food and drinks (Ma’kūlāt-o-Mashrūbāt) play a critical role. ‘Ilāj bi’l Taghdhiya (dietotherapy), a component of ‘Ilāj bi’l Tadbīr (regimenal therapy), emphasizes therapeutic dietary interventions for disease management and prevention. This review highlights the application of dietotherapy in the Unani system for the management of prevalent lifestyle disorders such as diabetes mellitus, hypertension, and obesity.