Abstract: Antibiotic resistance has become a serious global concern. It is important to identify new sources of natural antioxidants and antimicrobials. The present study describes for the first time the antioxidant, and antibacterial activities of various extracts of Monodora myristica a traditional medicinal plant. Each prepared concentration of the different extracts was tested for its antimicrobial activity against Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Pseudomonas aeruginosa and Escherichia coli (E. coli) on nutrient agar plates using disc diffusion method. At 50mg/ml showed inhibition of 13 and 15 mm against E. coli only for dichloromethane and methanol extracts respectively. The standard ciprofloxacin at 1mg/ml showed inhibition to all four tested pathogens, while antioxidant activity was analyzed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. A mixture of phytochemicals like phenols, alkaloids, flavonoids, glycosides were found in dichloromethane and methanolic extract of Monodora myristica which also showed remarkable potential with antioxidant and antimicrobial activities. The current study provides initial data that justify the use of Monodora myristica folkloric medicine. Our results showed that Monodora myristica has powerful antibacterial bioactivity against E. coli and antioxidant activity. Further investigations are needed to identify and characterize these constituents.