Muhammad Qasim, Almas Tabassum, Areeb Muhammad Qasim, Muhammad Hamza, Muhammad Taha
Glob Acad J Med Sci, 2026; 8(3): 113-123
DOI : https://doi.org/10.36348/gajms.2026.v08i03.002
Vitreoretinal surgery often achieves anatomical success; however, functional recovery differs markedly among eyes with similar disease presentations. Retinal imaging biomarkers help reduce this uncertainty by characterizing tissue composition, photoreceptor integrity, traction, perfusion, inflammation, and postoperative remodeling before these changes are evident in visual acuity. This structured review compiles evidence from 2020 to 2025 regarding optical coherence tomography, optical coherence tomography angiography, wide-field imaging, fundus autofluorescence, and emerging computational evaluations for predicting outcomes after surgery for epiretinal membrane, macular hole, rhegmatogenous retinal detachment, and tractional diabetic retinal disease. A translational framework is used, distinguishing preoperative risk stratification, intraoperative confirmation, early postoperative assessment, and longitudinal recovery. Across indications, the most consistent favorable prognostic indicators include preserved ellipsoid-zone and external-limiting-membrane continuity, limited inner retinal disorganization, reduced chronicity-related tissue deformation, smaller or more favorable lesion geometry, and early restoration of normal foveal architecture. In contrast, ectopic inner foveal layers, extensive disorganization of retinal inner layers, persistent subretinal fluid, outer retinal corrugation, hyperreflective inflammatory deposits, severe macular ischemia, and segmentation-unstable edema are associated with slower or incomplete recovery. No single metric demonstrates sufficient robustness across diseases, devices, and surgical techniques. The most effective prognostic approach merges with structural condition, lesion geometry, perfusion, symptom-relevant function, and temporal change. Standardized acquisition, masked grading, artifact reporting, external validation, and outcome definitions extending beyond distance acuity are necessary before imaging-derived scores can independently guide consent, timing, or individualized follow-up.
Diso, S.U, Liman, A.I, Ali, M
Glob Acad J Med Sci, 2026; 8(3): 106-112
DOI : https://doi.org/10.36348/gajms.2026.v08i03.001
Foodborne diseases are illnesses resulting from the consumption of food contaminated with pathogenic microorganisms, their toxins, or harmful chemicals. The study was aimed to investigate the phytochemical constituents and antibacterial efficacy of some spices (Zingiber officinale, Allium sativa, Piper nigrum and Syzygium aromaticum) extracts against some food borne pathogens (Klebsiella spp, Salmonella spp, Shigella spp, and Escherichia coli). Ethanol extracts from the spices were prepared, screened for phytochemical constituents using conventional methods and tested for antibacterial activity using agar well diffusion methods. Phytochemical screening of the extracts showed that the extracts contain Alkaloid, Anthraquinone, saponin, tannin, phenol, steroid, flavonoid and terpenoid. Alkaloid was found to be the most abundant constituent. The result of Antibacterial activity of the extract showed that the extract demonstrated activity against the isolates. Based on the susceptibility of the organisms to the extracts, E. coli was found to be the highest susceptible organisms, followed Salmonella typhi while least activity was shown by Klebsiella. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts range from 3.125 to 50 mg/ml. There is no significant difference on the susceptibility of the organisms against the extracts at p < 0.05. The results of present study have provided the justification for therapeutic potential of the extracts and also its use as dietary supplement for food flavouring and preservation.
Azuogu Faustina Oluomachi, Timighe Gift Cornelius, Azuogu Victoria Chioma, Azuogu Benedicta Chiamaka, Azuogu Francisca Daberechi, Mazi Njideka Calista
Glob Acad J Med Sci, 2026; 8(2): 99-105
DOI : https://doi.org/10.36348/gajms.2026.v08i02.006
Background: Healthcare-associated infections (HAIs) remain a major public health challenge worldwide, contributing significantly to patient morbidity, mortality, prolonged hospitalization, and increased healthcare costs. Nurses play a central role in the implementation of Infection Prevention and Control (IPC) measures; therefore, adequate awareness of IPC principles is essential for ensuring patient safety and reducing infection transmission within healthcare facilities. Objective: This study assessed the level of awareness of Infection Prevention and Control among nurses at a tertiary healthcare institution in Southern Nigeria and identified existing knowledge gaps that may hinder effective IPC implementation. Materials and Methods: A descriptive cross-sectional survey was conducted among 197 registered nurses at the Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria. Participants were selected using a simple random sampling technique. Data were collected using a structured self-administered questionnaire comprising socio-demographic variables and ten awareness-related items. Responses were measured on a five-point Likert scale. Data were analyzed using descriptive statistics, including frequencies, percentages, means, and standard deviations. A mean score of 3.0 and above was considered indicative of good awareness. Results: The overall awareness of IPC among nurses was high, with a global mean score of 3.76 ± 1.05. The highest awareness was recorded for the importance of hand hygiene in preventing infections (4.32 ± 0.78), familiarity with the proper use of personal protective equipment (4.09 ± 0.93), and understanding the rationale behind regular IPC training (4.04 ± 0.92). However, lower awareness scores were observed regarding adequacy of IPC training received (3.43 ± 1.14), being up-to-date with current IPC guidelines (3.43 ± 1.18), and regular review of IPC protocols (3.43 ± 1.18). Overall, 148 (75.2%) nurses demonstrated good awareness, while 49 (24.8%) had poor awareness. Conclusion: Nurses demonstrated good overall awareness of Infection Prevention and Control measures. Nevertheless, important gaps exist in continuous professional development, access to updated IPC guidelines, and routine review of institutional protocols. Strengthening regular training and dissemination of current IPC information may further improve awareness and support effective infection prevention practices.
Majid Suleman
Glob Acad J Med Sci, 2026; 8(2): 88-98
DOI : https://doi.org/10.36348/gajms.2026.v08i02.005
Atrial fibrillation is a frequent presentation in emergency departments and cardiology clinics, yet the transition from acute recognition to durable stroke prevention remains uneven. In Saudi Arabia, the rising burden of cardiometabolic disease, ageing, renal impairment and fragmented follow-up creates a setting in which anticoagulation decisions are clinically important and operationally fragile. This review examines anticoagulation gaps, stroke-risk assessment and guideline-based care for adults with atrial fibrillation managed in Saudi emergency and cardiology settings. A structured narrative method was used to synthesise international guidelines, contemporary emergency-care evidence and Saudi literature published from 2020 to 2025. The review identifies recurring gaps: incomplete documentation of CHA2DS2-VASc or CHA2DS2-VA scores, uncertainty around direct oral anticoagulant dosing, persistent use of non-anticoagulant antiplatelet therapy for stroke prevention, delayed initiation after emergency discharge, limited renal-function reassessment, and variable cardiology follow-up. These gaps are not merely prescribing issues; they reflect competing priorities at presentation, inconsistent ownership between emergency physicians and cardiology teams, patient concerns about bleeding, and limited structured counselling. Guideline-based care should begin at first contact, with electrocardiographic confirmation, haemodynamic stabilisation, systematic stroke and bleeding risk assessment, renal and hepatic review, medication reconciliation, shared decision-making and a defined follow-up appointment before discharge. A Saudi model should combine emergency pathways, pharmacist-supported anticoagulant initiation, cardiology review for rhythm strategy, and quality indicators that track eligible anticoagulation, dose correctness and early review. Strengthening this pathway could reduce preventable stroke, avoid unnecessary admission and improve continuity for patients who currently move between episodic acute care and chronic cardiovascular management.
Background: Chimeric Antigen Receptor T-cell (CAR-T) therapy, developed to address malignancies evading the immune system, has shown remarkable efficacy. However, its impact on infectious complications, particularly Clostridioides difficile infection, lacks real-world evidence. Our study aims to fill this knowledge gap by exploring prevalence, mortality rates, associated risk factors, and outcomes of C. difficile infections in CAR-T therapy patients. Methods: This retrospective analysis utilized National Inpatient Sample (NIS) data (2017-2019). We applied ICD-10 CM codes to identify CAR T therapy-related hospitalizations and Clostridioides difficile cases. Outcomes of interest included in-hospital mortality, length of hospitalization, total charges, and complications, associations, and interventions. Statistical analyses involved univariate and multivariate assessments, incorporating potential confounders such as age, gender, and Charlson Comorbidity Index score. Proportions and continuous variables were compared using appropriate tests with a significance level of P < 0.05. We conducted our statistical analysis using STATA Version 17 (College Station, TX: Stata Corp LLC). Results: We identified 685 inpatient cases of CAR-T therapy, among which 33 developed C. difficile infection, indicating an incidence of 4.8%. Mortality in the C. difficile group was 18.2%, significantly higher than the 2.8% in the non-C. difficile group (adjusted odds ratio: 7.67, 95% CI: 2.30 to 25.62, P<0.01). The mean length of stay for C. difficile cases was 30.9 days, compared to 19.1 days without C. difficile (coefficient: 11.01 days, 95% CI: 3.63 to 18.40, P<0.01). Total hospital charges were higher in the C. difficile group ($1,148,749) than the non-C. difficile group ($862,724), but not statistically significant (coefficient: $252,066, 95% CI: -78,332 to 582,464, P=0.134). Risks and outcomes associated with C
Oncolytic virotherapy (OV) is an emerging and innovative approach to cancer treatment. By inducing virus-mediated immune responses, oncolytic viruses enhance tumor specificity, stimulate antitumor immunity, and selectively infect and lyse cancer cells. In this study, we conducted a systematic review of oncolytic virotherapy, summarizing the major types of oncolytic viruses and their applications in combination therapies. Different viral vectors possess distinct biological characteristics, and diverse strategies have been employed in the design and optimization of OVs. Given their ability to modulate immune responses and the tumor microenvironment, oncolytic viruses show strong potential when combined with conventional cancer treatments. In particular, combinations of OVs with immunotherapies and CAR-T cell therapies are discussed in detail. Nevertheless, the selection of combination strategies should take into account tumor location, standard treatment modalities, and the expression of relevant biomarkers to maximize therapeutic efficacy.
Wajahat Usman, Mustaffa Fahim, Dua Jabbar, Sheema Gul, Sobia Saeed, Aysha Khan, Irej Waheed
Glob Acad J Med Sci, 2026; 8(2): 57-67
DOI : https://doi.org/10.36348/gajms.2026.v08i02.002
Workplace violence against healthcare workers is a serious threat to safety, efficiency, and health system performance worldwide. This study looks at the causes and effects of workplace violence in Pakistan’s hospital sector, where public and private facilities face very different challenges. We surveyed 768 healthcare workers from six hospitals in Peshawar—three public and three private. We collected detailed information on their experiences with violence, the quality of their institutions, how they report incidents, and the personal effects over a twelve-month period. Our findings show a clear divide between public and private hospitals. Workers in public hospitals face physical violence more than four times as often as those in private hospitals. More than half of public hospital staff reported experiencing attacks, compared to just 12 percent in private facilities. This divide appears in all areas: Witnessing violence, how incidents are reported, and the availability of safety measures and formal complaint systems. We created a model to explain how poor institutional quality leads to high levels of violence and low reporting, and we confirmed these predictions with our data. Statistical analysis shows that factors like hospital type, security measures, and reporting procedures account for almost all variations in violence outcomes. Individual characteristics such as gender, profession, and experience do not have an independent impact. Having formal reporting systems increases the actual reporting of incidents by nearly ten times. We also found that workers who are physically attacked face significant psychological issues, including heightened fear of work and dissatisfaction with their jobs. This suggests serious challenges for keeping workers in their roles. These findings indicate that structural problems, rather than individual weaknesses, are the main cause of workplace violence in healthcare settings in Pakistan. Policymakers should focus on creating mandatory reporting systems, investing in visible security measures, and offering psychological support to affected staff, especially in the public hospital sector, which is severely under-resourced.
Top Editors
Dr Akhtar Ali
Associate Editorial Board
MBBS, MD (Pharmacology) Senior Medical Officer District Hospital Baran, District- Baran (Rajasthan) 325205, India Email: drakhtar06@gmail.com
Dr Hozifa Mohammed Ali
Associate Editorial Board
Teaching Assistant, Department of Surgery, Alzaeim Al azhari University, Khartoum, Sudan Email: hozifa.m.ali@gmail.com
Dr. Tej Nath Nepal
Associate Editorial Board
Chie Medical Officer, Gedu Hospital, Ministry of Health, Royal Government of Bhutan Email: tnnepal@health.gov.bt
Dr. M. Shabnum
Associate Editorial Board
Assistant Professor, Department of Microbiology, Narayana Medical College, Nellore-524003, Andhra Pradesh, India Email: shabnummusaddiq@gmail.com
Dr Anslem Ajugwo
Associate Editorial Board
Department of Medical Laboratory Science, Madonna University Nigeria E-mail:slemjugwo@yahoo.com
Dr. Devika Singh
Associate Editorial Board
Senior Resident, Department of Dentistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India Email: devsika@yahoo.co.in
Dr. Nkporbu A.K. (AmbP)
Associate Editorial Board
Consultant Neuropsychiatrist/Mental Health Physician, Dept. of Neuropsychiatry/Mental Health, University of Port Harcourt Teaching Hospital, Nigeria Email: nakpigi2008@yahoo.com
Dr. Serkan Yazici
Associate Editorial Board
Dermatology and Venereology, Uludag University School of Medicine, Özlüce, Görükle Kampüsü, 16059 Nilüfer/Bursa, Turkey Email: serkanyazici@uludag.edu.tr
Dr. Anil Gowtham Manivannan
Executive Editor
Consultant Orthopaedic Surgeon, Arathana Hospital, Pollachi, Tamil Nadu, India Email: anilthambu91@yahoo.com
Tariq Dhiyab Al-Saadi
Deputy Chief-Editor
Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital- McGill University, Montreal, Canada Email: t.dhiyab@hotmail.com
Mohammed Ahamed Ahamed Abuelnour
Editor-in-Chief
Assistant Professor of Anatomy, College of Medicine, Dar-Al Uloom University, Kingdom of Saudi Arabia (KSA) Email: abuelnour88@yahoo.com
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