Motor neuron disease (MND), often known as amyotrophic lateral sclerosis, is a degenerative neurological illness for which there is no recognized cause (ALS). Increased muscular weakening and bulbar dysfunction lead to respiratory failure, which is the most common cause of mortality [1]. It may be difficult to establish the diagnosis until all of the clinical signs and symptoms are present. One should always get a professional neurology opinion for all types of ailments since there is a wide differential diagnosis to consider, including treatable conditions. Though it is possible that only a small percentage of people with familial ALS can be shown to have an inherited gene disorder, research into the molecular basis of genetic subgroups is yielding vital discoveries that might one day lead to medications for those with sporadic cases [2]. A multidisciplinary team provides supportive care in the absence of a cure or treatment that may alter the course of the illness. Motor neuron illness may be caused by a combination of genetic and environmental factors, and future treatment may involve a combination of molecular medications and stem cell transplantation. A progressive degenerative disease, such as MND or ALS, has no known cause in the patients who suffer from it. When examining the differential diagnosis of motor neuron illnesses, it is necessary to consider the relative involvement of upper and lower motor neurons.